Purdue vs Notre Dame Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Purdue vs Notre Dame

Purdue clash with Notre Dame in this NCAAF Week 4 matchup at Notre Dame Stadium, with kickoff scheduled for 03:30 on Sunday 21 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Bet on a Higher Total than the Line Suggests

We’re forecasting that Notre Dame and Purdue will produce a significant combined points total. Therefore, our prediction is to take the 1.88 that there are Over 51.5 points.

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66-7 Notre Dame Win When Teams Last Clashed

Purdue Boilermakers lost when they last took to the field. At Ross-Ade Stadium, they were turned over 33-17 at home to USC Trojans.

Notre Dame Fighting Irish were beaten 41-40 at Notre Dame Stadium in their last game. This loss at home to Texas A&M Aggies was their second straight defeat.

Head-to-Head Statistics

Notre Dame beat Purdue in their last head-to-head matchup. It was a 66-7 scoreline at Ross-Ade Stadium.

Quarterbacks

Ryan Browne

CJ Carr

Purdue vs Notre Dame Prediction & Picks

Our Purdue vs Notre Dame tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

Over 51.5 points seems like a realistic outcome for this college football showdown. We’re taking odds of 1.88 on the basis that the total line is too low.

The CFB handicappers at jetwinbet.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.

Key Purdue vs Notre Dame stats:

• The 51.5 line has been covered in 3 of the last 5 Purdue games on the road.
• The 51.5 line has been covered in 11 of the last 20 Purdue games on the road.
• The 51.5 line has been covered in 3 of the last 5 Notre Dame games at home.
• The 51.5 line has been covered in 6 of the last 10 Notre Dame games at home.
• The 51.5 line has been covered in the last 2 Notre Dame games at home.

Over 51.5 Probability

If you go by the best sportsbooks, our pick has a 53.2% prospect of winning. However, our analysts have this number closer to 60% based on their in-depth research. It is the reason why we are recommending this college wager.

The sportsbooks allow you to shoot for bigger odds by moving the line on the Totals. Choose a number where you’re happy and get more juice.

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Best Bet

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Player Prop Picks

Correct Score Prediction

Purdue 13 - 45 Notre Dame

Correct score betting might be tough to predict but there’s a tasty potential return if you get it right. We’ll try the Irish to achieve a 45-13 victory at massive odds.

Purdue vs Notre Dame Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Notre Dame Big Favorites on the Moneyline

The latest Moneyline betting odds give Notre Dame a 97% chance of winning this college game which means they’re overwhelming 1.03 favorites with the sportsbooks. For those wanting to back Purdue, you will find 13.80 about the underdogs.

There is a spread of 24.5 and total points has a line of 50.5. The beauty of the Totals is that you only have to choose from one of two options. If you're keen on Over 50.5, this selection is available at 1.91.

If you’re getting ready to place a college football bet, head over to one of the top betting apps and explore the wide variety of game lines and team props. Take your time to spot the most appealing opportunities.

Jeremiyah Love Favorite to Be First Touchdown Scorer

Jeremiyah Love can be backed to score a touchdown at anytime at 1.26. He is the favorite to score the first TD at odds of 3.30.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Micro Betting

For those looking to enjoy a thrilling in-game wager, then college football micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.

Notre Dame Have Eight Wins From Last Ten Home Games

Notre Dame own a 8-2 mark in their past 10 home games, averaging 36.50 points scored and 14.70 points allowed.

Purdue have dropped ten consecutive away games. They have zero win and ten losses in the last 10 road games, scoring 14.90 points per matchup and conceding 39.00.

In their last matchup at Notre Dame Stadium, Notre Dame came out on top 27-13 against Purdue.

Last 10 Games		W-L	P	PF	PA	O51.5	U51.5
Notre Dame Home Stats		8-2	51.20	36.50	14.70	5	5
Purdue Away Stats		0-10	53.90	14.90	39.00	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O51.5 = Games Over 51.5 Points
• U51.5 = Games Under 51.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Purdue Boilermakers Stats

Notre Dame Fighting Irish Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 0 wins and 10 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +25.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +25.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -25.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -25.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 52.30 pts in the previous 10 games
• Game Totals on the Road: An average of 53.90 pts in the previous 10 games on the road
• Over 51.5: Covered in 3 of the previous 10 games
• Over 51.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 17.80 pts and allowed 34.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 14.90 pts and allowed 39.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 56.80 pts in the previous 10 games
• Game Totals at Home: An average of 52.10 pts in the previous 10 home games
• Over 51.5: Covered in 5 of the previous 10 games
• Over 51.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 34.90 pts and allowed 21.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 34.80 pts and allowed 17.30 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Independents I-A	W	L	PF	PA	N. Pts	Home	Away	Strk
UConn	2	2	151	109	42	2-0	0-2	1W
Notre Dame	1	2	120	98	22	1-1	0-1	1W

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	4	0	219	33	186	4-0	0-0	4W
Maryland	4	0	130	43	87	3-0	1-0	4W
Ohio State	3	0	121	16	105	3-0	0-0	3W
Oregon	4	0	203	37	166	3-0	1-0	4W
Penn State	3	0	132	17	115	3-0	0-0	3W
USC	4	0	210	81	129	3-0	1-0	4W
Washington	3	0	167	55	112	2-0	1-0	3W
Rutgers	3	1	167	96	71	3-1	0-0	1L
Nebraska	3	1	174	54	120	2-1	1-0	1L
Michigan State	3	1	137	115	22	3-0	0-1	1L
Michigan	3	1	140	71	69	2-0	1-1	2W
Iowa	3	1	132	58	74	2-0	1-1	2W
Illinois	3	1	145	85	60	2-0	1-1	1L
Minnesota	2	1	103	37	66	2-0	0-1	1L
Purdue	2	2	112	106	6	2-1	0-1	2L
Wisconsin	2	2	83	75	8	2-1	0-1	2L
Northwestern	1	2	59	64	-5	1-1	0-1	1L
UCLA	0	3	43	108	-65	0-2	0-1	3L